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What are Exosomes?

Exosomes are lipid vesicles that shuttle proteins and genetic information between its neighbors and distant cells. Why is this important for an exosome to move protein around? And why is it important for my cells to send genetic information down the street to the neighboring cells? It’s simple really. Because we are a whole being with trillions of microscopic actions, changes happening at any given second to find homeostasis. Meaning your body wants to not only survive, but to thrive.

Let’s take a look at what we thought we knew about the body 10 years ago. We thought the appendix was a silly little organ that served no purpose that could rupture and kill us potentially. Now, we understand that this organ helps balance the good vs bad bacteria in the gut. Web MD has this to say, “Normally, the appendix sits in the lower right abdomen. The function of the appendix is unknown. One theory is that the appendix acts as a storehouse for good bacteria, “rebooting” the digestive system after diarrhea. Other experts believe the appendix is just a useless remnant from our evolutionary past.” I wonder what year those so called experts that refute THEORETICAL science were born? Perhaps they are in denial still that science has evolved past their own ingrained beliefs.

If the appendix is in fact a warehouse of good bacteria the intestines need to be able to communicate it’s current situation with the appendix so that it may release the good bacteria as needed. These vehicles of communication are sort of like telegrams. The telegram will be sent back and forth to communicate the current condition and operation instructions. Check out this current study to learn more about some of the latest research into organ communication:
https://www.sciencedirect.com/science/article/abs/pii/S1534580719300048

So now you understand that these exosomes shuttle information. I’m sure you can understand that if we look at a joint specifically the implications that has. If not, lets dive a little deeper.

Even if you have arthritis you likely still have some good healthy tissue cartilage in your knees, shoulders etc. So if some of the tissue is damaged and some is good do you think it’s important that the tissue communicates? Yes, because stem cells potentially have the ability to heal the damaged tissue. The communication of the good cartilage, the stem cells and the dying/damaged cartilage cells is essential so the body knows not only how to heal the existing tissue, but to replace or reproduce it.

To recap, exosomes serve as a lipid transporter of messages to direct and distant neighboring cells. These vesicles are found in the extracellular matrix which are produced by immune cells like dendritic cells, B cells and mast cells. These cells are commonly found in the blood, urine and cerebrospinal fluid.

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